High entropy alloys thin films (HEA-TFs) recently gained attention due to their combination of mutually exclusive properties such as high strength, ductility, and thermal stability [1]. However, a fine control over the microstructural features of HEAs-TF is still an open challenge, requiring the implementation of new nanoengineering strategies. In this context, pulsed laser deposition (PLD) was employed for the synthesis of CoCrCuFeNi HEA-TFs with nanosized grains and a wide range of microstructures such as compact and nanogranular, obtained simply by controlling the background pressure during deposition (from 2*10-3 up to 10 Pa). These HEA-TFs show a high hardness (~11 GPa), which is higher than sputter-deposited counterparts (hardness ~8.3 GPa) and other literature results due to the small domain size (from 38 to 12 nm), leading to Hall-Petch strengthening. Micropillar compression tests reveals high yield strength, up to 2.0 GPa, without sacrificing plastic deformability (no fractures at 30% compression). Nanogranular films show high thermal stability due to the cluster assembled structure and the lattice distortion of HEAs, with grain growth starting from 47% of Tmelt (370°C). The second nanoengineering strategy consists on the synthesis of Al/Alx(CoCrCuFeNi)100-x nanolaminates (NLs) with semi-coherent (FCC/FCC, x=0%) and incoherent (FCC/BCC, x=25%) interfaces, aiming to block the propagation of dislocations to improve hardness and yield strength [2]. This was achieved by controlling the bilayer period (Λ), from 400 nm down to 2.5 nm to further hinder cross-layer dislocation propagation. Among the main results, in situ micropillar compression tests show that incoherent interfaces have a greater capability to improve yield strength (up to 2.2 GPa), while showing great plastic deformability, with no appearance of cracks even at >30% deformation. [1] Zou Y., Nanocrystalline High-Entropy Alloys: A New Paradigm in High-Temperature Strength and Stability, Nano letters, Vol. 17, 2017 [2] Sàenz-Trevizo A., Hodge A. M., Nanomaterials by design: a review of nanoscale metallic multilayers, Nanotechnology, Vol 31, 2020