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A thermomechanical simulation strategy is proposed to couple grain structure and anisotropic mechanical behavior at the part scale for the laser powder bed fusion (L-PBF) process. First, the part-scale grain structure is generated using a hybrid - Cellular Automaton (CA) method, which allows the grain structure to be generated on a CA grid at the part-scale while incorporating the detailed scanning trajectories. The grain information is then transferred to a mechanical finite element mesh using a reduced grain method, which demonstrates the effect of the grain structure on the mechanical response, and its effect is compared with that of a single crystal. In order to take into account the effect of full grain information, the texture component method [1] considering the grain distribution for each element in the mechanical mesh is proposed, and its effectiveness and efficiency are analyzed in the part-scale simulation of the L-PBF process.